The pathophysiology of anemia and the basis of its clinical investigation. Pruebas que evalúan el estado del hierro: Hierro del compartimiento funcional: Ferremia: Capacidad total de saturación de hierro (CTSH). Transcript of Clasificacion de anemias. Disminución de la capacidad transportadora de oxigeno de la sangre. Adaptaciones fisiológicas.

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This is summarized in the next diagram. Faced with microcytic anemia, the three main diagnostic possibilities include iron deficiency anemia IDAthalassemia, and anemia of chronic disorders ACD. Su capacidad de reserva en el organismo frente a una dieta desprovista de el, no supera los tres meses.

The next step is the calculation of reticulocyte production index RPI: What remains in the plasma spontaneously degrades into metheme and globin. A perspective on iron deficiency anaemia. Depending on clasificzcion result, a bone marrow study may be necessary to detect hematological diseases or metastasis.

It is as if the body were trying cclasificacion make up in blood quantity what it lacks in quality.

The bleeding can be intense, with a sharp drop of hematocrit and obvious clinical signs; or of small intensity and chronic, with progressive decrease in hematocrit and MCV, which may go unnoticed. Celiac disease, gastrectomy, H pylori colonization Infrequent: Moreover, the increased production of urobilinogen that results is reflected by increased urobilinogen concentration in the urine. Physiologic compensation for decreased rbc mass Each physiologic mechanism will be discussed below.


Despite ferritin being an acute phase reactant, the diagnosis of IDA is unlikely with normal or elevated ferritin levels. Low hematocrit is a subrogate value for anemia, but it is not measured directly by the hematological analyzer.

Serum haptoglobin concentration When an rbc is destroyed, the liberated hemoglobin binds mole-for-mole with a serum protein, haptoglobin.

Classification of anemia for gastroenterologists

Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy. In some patients, the cause of anemia is complex chronic disease and chronic hemorrhage. In a patient with anemia anemais fever of unknown origin, we must carry out careful microscopic examination of bone ansmias, some selective staining, and bone marrow cultures to diagnose any underlying infectious diseases.

In the case of hemolysis which takes place in the bloodstream rather than in the RESso-called intravascular hemolysisadditional biochemical phenomena are observed see diagram, below.

Because of this, your appreciation of these clinical signs will serve you better in diagnosing this type of anemia than will the laboratory. In adult life, the esophagus, stomach, bowel and liver are involved in the pathogenesis of different types of anemia caused by nutritional anmeias, bleeding or chronic inflammation.

Eur J Clin Nutr. Acquired autoimmune, mechanical destruction, toxic-metabolic, drugs, infectious, PNH, hypersplenism.

Classification of anemia for gastroenterologists

Evaluation of the gastrointestinal tract in casificacion with iron-deficiency anemia. Free hemoglobin in excess of that which binds haptoglobin is rapidly filtered into the urine. On the other hand, we can improve the quality of life of patients by correcting the anemia with medical treatment or regular transfusions.


When symptoms do develop, they are pretty claisficacion what you would expect given the precarious state of oxygen delivery to the tissues: Iolascon A, Perrota S.

In anemia of renal failure, morphological alterations in the blood are scarce and serum erythropoietin may be normal, but inappropriately low for the degree of anemia. The anemia of chronic disorders. It is difficult to arrive at the definitive diagnosis. Therefore, we should keep in mind ACD as the most likely diagnosis in elderly and inpatients, and as the second most likely diagnosis in outpatients under 65 years of age[ 68 ].

Measurement of total body rbc mass requires special radiolabeling techniques that are not amenable to general medical diagnostic work.

The impairment of pluripotent stem cells usually produces pancytopenia anemia, leukopenia and thrombocytopenia. ACD is the most prevalent form of anemia after IDA in the general population[ 4068 ], but is even more common in hospitalized patients, regardless of sex and age[ 42676970 ].

Ed inflammatory disease is a widespread cause of chronic disease anemia.