COMPOSTO DE GRIGNARD PDF
5 jul. 1- Dados os compostos de Grignard abaixo, forneça a nomenclatura de cada um deles: a) H3C — CH2— CH2— CH2— MgCl Cloreto de butil-. Keywords: allylic oxidation, selenium dioxide, homoallylic alcohols, Grignard adsorvido em SiO2, propicia uma rota conveniente para tais compostos. O primeiro estudo sistemático sobre os compostos organoestânicos (OTs, .. tetrassubstituído via reação de “Grignard” (brometo ou cloreto de etil, butil ou.
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Preparation of aromatic geraniol analogues via a Cu(I)-mediated Grignard coupling
The Sharpless conditions for oxidation of geranyl acetate employs 0. Kascheres on occasion of his 60 th birthday.
The chosen protecting groups clearly influence the oxidation process. Then a solution of 2 E – 3,7-dimethyl-2,6-octadienyl tetrahydro-2 H pyranyl ether 12 New York,p.
February 4, Published on the web: Preparative column chromatography was carried using silica gel 60 Merckmesh. The extracts were washed with a saturated aqueous solution of FeSO 4. The mixture was treated drop wise with cold metanol 1 mL and extracted with hexane. Geranyl bromide 4 was necessary in the next steps and its preparation although it coomposto commercially available was achieved after some attempts in order to optimize the conditions for getting high yield.
To a stirred solution of 14 3. Then BuLi in hexane 2. Conclusion In brief, we optimized a selective grignarv of allylic methyl groups in geraniol derivatives over a solid support ckmposto the corresponding trans- veb -unsaturated alcohols and aldehydes, using selenium dioxide and t -butylhydroperoxide adsorbed on silica gel as oxidants. However, “nontarget” organisms may be exposed, resulting in the poisoning of biological system, originating mutations and sentencing species to extinction.
In brief, we optimized a selective grigjard of allylic methyl groups in geraniol derivatives over a solid support to the corresponding trans- ab -unsaturated alcohols and aldehydes, using selenium dioxide and t -butylhydroperoxide adsorbed on silica gel as oxidants. Naturstoffe22 The solvent was removed under vacuum and the residue was diluted in ether 50 mL and water 30 mLthen extracted with ether 2×30 mLdried over MgSO 4 and filtered, and then the solvent was removed under reduced pressure.
Further studies on phenolic oxidation of these synthetic intermediates to achieve the synthesis of cyclic isoprenoids will be reported in due course.
The mixture was stirred for 48 h. Some OTs are used as pesticides in crops, or as biocides in antifouling paints, applied in the ship hulls to avoid attachment and growth of tube worms, mussels and barnacles. The ether phase was washed with water 30 mLthen with brine 2×30 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory evaporation. New York,vol. Nova22 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
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In this work we reported a revision study on the history of OTs and the techniques developed for its assessment and control. Fall30 To a two-necked mL round bottom flask with 2-iodophenyl tetrahydropyranyl ether 6 3. S The same procedure as employed for allylic oxidation of 1 was used ; compound 13 3.
Em Organotin Compounds ; Sawyer, A. Difunctional allylic terpenes are important synthetic building blocks. The solvent was removed conposto reduced pressure and the residue was diluted with ether 50 mL and water 30 mL and extracted with ether 2×50 mL.
Bromination of geraniol 15 with phosphorus tribromide 0. Results and Discussion The Sharpless conditions for oxidation of geranyl acetate employs 0. Economic Entomology81 The organic layer was washed with two portions of brine then dried with anhydrous MgSO 4.
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The reaction was cooled, a saturated solution of NH 4 Cl was added, the solutions was extracted with ether 3×50 mLdried over MgSO 4filtered and the solvent was removed under reduced pressure by rotatory compposto. Geraniol was purchased from Aldrich Chem. Alkylation of sodium salts, however, invariably leads to complex mixtures containing both ring and oxygen substituted products.