Los ácidos micólicos, en específico, poseen funciones biológicas importantes, entre las que se encuentra el papel que desempeñan en la persistencia de la. como los ácidos micólicos, ácido micoserósido, fenoltiocerol, lipoarabinomanano y arabinogalactano contribuyen a la longevidad, a la respuesta inflamatoria. Aunque el análisis de los lípidos de la pared celular (ácidos micólicos) mediante cromatografía líquida de alta presión es una opción Buena y bien conocida, los.

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The magic bullets and tuberculosis drug targets. Water Res ; The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Strategies in the search for new lead compounds or original working hypothesis. A mechanism of drug action revealed by structural studies of enoyl reductase. The history of the Ziehl-Neelsen stain.

Brennan PJ, Nikaido H. These results indicate the relevance of continuing immunoprotection studies with mycobacterial lipid antigens. Nat Rev Microbiol ; 4: Currently, lipid antigens of mycobacteria are attractive targets for the development of new tuberculosis vaccinal formulations. The mechanism of isoniazid killing: Surface glycopeptidolipids of M. Tuberculosis, Mycobacterium smegmatis, lipids. Crystal structure and fuction of the isoniazid target of Mycobacterium tuberculosis.

Entre estos factores se encuentran: Tal es el caso del estudio desarrollado por Mederos y cols.

Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: Advances in tuberculosis vacine strategies. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.


Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages. Micplicos studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP CoA reductase from Mycobacterium tuberculosis.

Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial species.

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Role of a branching mannosyltransferase. Chemoterapy of experimental tuberculosis. Recent advances in new structural classes of anti-tuberculosis agents.

Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives.

Services on Demand Journal. Infect Dis Clin N Am ; Rational approach in the new antituberculosis agent design: J Gen Appl Microbiol ; Lipid biosynthesis as a target for antibacterial agents. Quantitative structure -based design: A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-acp reductase.

The synthesis of acid hydrazides, their derivatives and related compounds. Clarity through the scope of genetics. Obtainment and partial characterization of a lipidic fragment of the outer membrane of Mycobacterium smegmatis. De acuerdo con los resultados obtenidos mediante el empleo de la cromatografia en capa delgada y el Dot blot, se puede afirmar que se obtuvo un extracto de pared de M. Heterocyclic acid hydrazides and derivatives. Lepr Rev ; 68 4: Chemotherapy of experimental tuberculosis – V.

  AFI 91-207 PDF

Effect of Mycobacterial phospholipids on interaction of Mycobacterium tuberculosis with macrophages. Evaluation of Mycobacterium smegmatis as a possible surrogate screen for selecting molecules active against multi-drug resistant Mycobacterium tuberculosis. Structural basis and mechanism of enoyl reductase inhibition by triclosan.

Pathogenic and potentially pathogenic microorganisms as contaminants of fresh water from different sources. Discovery of a novel and potent class of FabI-directed antibacterial agents.

Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.

Ácido micólico – Wikipedia, a enciclopedia libre

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosisacixos triclosan and isoniazid. Tuberculosis, focus on tropical diseases. Mechanistic diversity and regulation of Type II fatty acid synthesis. Characterization of a ligand-receptor binding event using receptor-dependent four-dimensional quantitative structure-activity relationship analysis.

Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. A triclosan-resistant bacterial enzyme.

Overexpression of inhA, but not kasAconfers resistance to isoniazid and ethionamide in Mycobacterium smegmatisM. Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by acicos and hexachlorophene.

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.