BIOPRECURSOR PRODRUGS PDF

THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform. By using our site, you consent to the use of cookies by us. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even reaching its target. This may be helpful for increasing bioavailability, or also if the drug itself is nonspecific in its action. biooprecursor

Prodrugs_Lecture |authorSTREAM

My presentations Profile Feedback Log out. Awesome, that makes a lot of sense. Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Download ppt “Bioprecursor Prodrugs”.

To make this website work, we log user data and share it with processors. Phosphorylation Activation ganciclovir substrate for DNA polymerase 5. About project SlidePlayer Terms of Service. Auth with social network: Why have such prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane?

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Disposition of Chemical Compounds. Registration Forgot your password?

Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Examples of Carrier-linked Bipartate Prodrugs 3.

Know some examples of currently used prodrugs PowerPoint Presentation: Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: What the body does to the drug? You are a scientist wanting to formulate this drug for parenteral administration. N-Oxidation pralidoxime acetylcholine esterase activator e.

To make this website work, we log user data and share it with processors. Happiness for me is largely a matter of digestion -Lin Yutang. What types of groups are the easiest to cleave from a carrier? If you wish to download it, please recommend it to your friends in any social system.

Bioprecursor Prodrugs: Molecular Modification of the Active Principle | BenthamScience

Go to Application Have a question? Share buttons are a little bit lower. Published by Aubrey Johnston Modified over 3 years ago. If you wish to download it, please recommend it to your friends in any social system. The presentation is successfully added In Your Favorites.

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Read This Before Posting. Upload from Desktop Single File Upload. Examples of Carrier-linked Bipartate Prodrugs 4. Registration Forgot your password?

Presentation Description Prodrugs, medicinal chemistry. Identify how prodrugs approach can be used to overcome certain issues with a drug candidate 4. Disposition of Chemical Compounds. Google doesn’t tell me the answer, oddly enough.

Bioprecursor Prodrugs: Molecular Modification of the Active Principle

Enzymes — not just your run of the mill protein! Examples of Carrier-linked Bipartate Prodrugs 6.

Oxidative Activation P c. Published by Aubrey Johnston Modified over 3 years ago.

Bioprecursor prodrugs: molecular modification of the active principle.

Sites of Administration Sites of action Cell membrane. Powered by SMF 2. Azo reduction prontosil sulfanilamide b. OK Is the passage of drug from its site bioprecufsor administration to its site of action through cell membranes. We think you prodrugss liked this presentation.

Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr. Know some examples of currently used prodrugs.

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