IDIOPATIK TROMBOSITOPENIA PURPURA ADALAH PDF
Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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Br J Haematol ; Persons with ITP who trombositkpenia 70 years or older are at increased risk for spontaneous bleeding and treatment-related adverse events. Journal Statistics View My Stats.
This is adlaah open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. However, other drug treatments are usually recommended instead. The epidemiology of immune thrombocytopenic purpura.
The IgG autoantibodies are also thought to damage megakaryocytesthe precursor cells to platelets, although this is believed to contribute only slightly to the decrease in platelet numbers.
Idiopathic thrombocytopenic purpura ITP is the condition of having a low platelet count thrombocytopenia of no known cause idiopathic. People with the disease have too few platelets in the blood.
However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines  and a normal bleeding time does not exclude a platelet disorder.
Adults are usually started on a steroid medicine called prednisone.
Children should be discouraged from rough contact sports or other activities that increase the risk of trauma. From Wikipedia, the free encyclopedia. The evolution of drug discovery: Other immunosuppresants, which are steroid sparing drugs like mycophenolate mofetil and idiopatjk, are becoming more popular for their effectiveness.
Idiopathic thrombocytopenic purpura
Initial treatment usually consists of the administration of corticosteroidsa group of medications that suppress the immune system. To date, the diagnosis of ITP is still arrived at by exclusion, i. It causes a characteristic purpuric rash and an increased tendency to bleed.
Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow.
Some children may need treatment. Footnotes Source of Support: Bleeding time is prolonged in ITP patients; however, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines as useless.
IDIOPATIK TROMBOSITOPENIA PURPURA PDF
The clinical signs of ITP are purpura, ecchymosis, petechiae and gastrointestinal tract bleeding, gingival bleeding, epistaxis, and urinary tract bleeding. Thrombocytopenia caused by immunologic platelet destruction. The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp.
The body destroys the platelets that carry the antibodies. This is because the underlying autoimmune mechanism that is destroying the patient’s platelets will also destroy donor platelets, and so platelet transfusions are not considered a long-term treatment option. Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause.
Am Soc Hematol ;— Bleeding into the brain may also occur. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines  and a normal bleeding time does not exclude a platelet disorder.
At least 70 percent of childhood cases will end up in remission within six months, even without treatment. The procedure is potentially risky in ITP cases due to the increased possibility of significant bleeding during surgery. Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT.
Recent research now indicates that impaired production of the glycoprotein hormone thrombopoietinwhich is the trombosito;enia for platelet production, may be a contributing factor to the reduction in circulating platelets.
The dose and mode of administration is determined by platelet count and whether there is active bleeding: In the United States, the adult chronic population is thought to be approximately 60,—with women outnumbering men approximately 2 to 1, which has resulted in ITP being designated an orphan disease.
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